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Bupropion should be discontinued and not restarted in patients who experience a seizure during treatment.
Other drugs that your selected drugs interact with Cymbalta (duloxetine) interacts with more than 500 other drugs.
Wellbutrin (bupropion) interacts with more than 300 other drugs.
Interactions between your selected drugs and foodduloxetine ↔ food Applies to: Cymbalta (duloxetine)GENERALLY AVOID: Use of duloxetine in conjunction with chronic alcohol consumption may potentiate the risk of liver injury.
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The total dose of bupropion should generally not exceed 450 mg/day (or 150 mg every other day in patients with severe hepatic cirrhosis).I am very nervous to do this to say the least but am desperate to get bak to normal and FINALLY feel happy again and not sad at every turn in my life. The estimated incidence of seizures is approximately 0.1% at dosages up to 300 mg/day and 0.4% at dosages between 300 to 450 mg/day, but increases almost tenfold between 450 mg and 600 mg/day.The risk may also be increased during coadministration with selective serotonin reuptake inhibitors (SSRI antidepressants or anorectics), monoamine oxidase inhibitors, neuroleptic agents, central nervous system stimulants, opioids, tricyclic antidepressants, other tricyclic compounds (e.g., cyclobenzaprine, phenothiazines), systemic steroids, and/or any substance that can reduce the seizure threshold (e.g., carbapenems, cholinergic agents, fluoroquinolones, interferons, chloroquine, mefloquine, lindane, theophylline).These agents are often individually epileptogenic and may have additive effects when combined.MANAGEMENT: Extreme caution is advised if bupropion is administered with any substance that can reduce the seizure threshold, particularly in the elderly and in patients with a history of seizures or other risk factors for seizures (e.g., head trauma; brain tumor; severe hepatic cirrhosis; metabolic disorders; CNS infections; excessive use of alcohol or sedatives; addiction to opiates, cocaine, or stimulants; diabetes treated with oral hypoglycemic agents or insulin).
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Wellbutrin is prescribed for Depression and Smoking and is mostly mentioned together with these indications. Always consult your doctor before taking these medications together.